Ross Dubois

RaeSedo Showcases Breakthrough Asthma Therapy at ATS Respiratory Innovation Summit

RaeSedo, Inc. has been selected to present its groundbreaking approach to asthma treatment at the prestigious 2024 ATS Respiratory Innovation Summit. This recognition underscores RaeSedo’s commitment to revolutionizing asthma care through innovative science and cutting-edge therapeutics. As one of 25 companies chosen for this highly competitive event, RaeSedo is proud to showcase its novel therapeutic …

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RaeSedo Inc. awarded $3.4M STTR Grant to Develop New Asthma Therapies

RaeSedo Inc., a spin-out of the University of Arizona developing novel therapies for asthma, is pleased to announce the award of a Phase 2 Small Business Technology Transfer (STTR) grant awarding $3.4 million over two years to continue developing potential therapeutics. Founded and led by researchers from the University of Arizona, RaeSedo Inc. moves into this next …

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Histology of genotype treated with IL-13

Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells

Surfactant Protein-A (SP-A) plays a crucial role in asthma, but genetic variation can lead to dysfunction. Researchers investigated a specific genetic change at position 223 in SP-A2, finding that individuals with the major variant (223Q) had better lung function, reduced inflammation, and improved asthma control. In mouse models and cells from asthmatic participants, they also showed that SP-A 223Q peptides had anti-inflammatory effects, suggesting their potential as therapeutic agents for asthma.

SSTR awarded to RaeSedo, LLC: Development of surfactant protein A-derived peptidomimetics for the treatment of asthma

Drs. Monica Kraft and Julie Ledford received SSTR funding for a Phase I proposal to develop new, short peptide derivatives and mimetics of the active region of surfactant protein-A (SP-A), a protein that regulates key innate immune functions in the lung, and perform a drug screen that identifies those most active and stable with similar …

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Surfactant Protein-A protects against IL-13-induced inflammation in asthma

The lung surfactant proteins are recognized as critical not only for their role in lowering lung surface tension but also in innate host defense. Reports have shown that some asthmatic patients have decreased levels of one member of this protein family in particular, surfactant protein-A (SP-A). Our studies set out to determine the contribution of …

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