Microscopic image of lung tissue from SP-A deficient (SP-A-/-) mice showing airway inflammation and structural changes, highlighting the absence of surfactant protein-A's protective effects against inflammation.

Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells

ByRaeSedo Inc. Press

Surfactant Protein-A (SP-A) is an innate immune modulator that regulates a variety of pulmonary host defense functions. We have shown that SP-A is dysfunctional in asthma, which could be partly due to genetic heterogeneity. In mouse models and primary bronchial epithelial cells from asthmatic participants, we evaluated the functional significance of a particular single nucleotide…

A scientist wearing gloves and a lab coat working with a microscope in a laboratory.

Surfactant Protein-A protects against IL-13-induced inflammation in asthma

ByRaeSedo Inc. Press

The lung surfactant proteins are recognized as critical not only for their role in lowering lung surface tension but also in innate host defense. Reports have shown that some asthmatic patients have decreased levels of one member of this protein family in particular, surfactant protein-A (SP-A). Our studies set out to determine the contribution of…