Microscopic image of lung tissue from SP-A deficient (SP-A-/-) mice showing airway inflammation and structural changes, highlighting the absence of surfactant protein-A's protective effects against inflammation.

Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells

ByRaeSedo Inc. Press

Surfactant Protein-A (SP-A) is an innate immune modulator that regulates a variety of pulmonary host defense functions. We have shown that SP-A is dysfunctional in asthma, which could be partly due to genetic heterogeneity. In mouse models and primary bronchial epithelial cells from asthmatic participants, we evaluated the functional significance of a particular single nucleotide…

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SSTR awarded to RaeSedo, LLC: Development of surfactant protein A-derived peptidomimetics for the treatment of asthma

ByRaeSedo Inc. Press

Drs. Monica Kraft and Julie Ledford received SSTR funding for a Phase I proposal to develop new, short peptide derivatives and mimetics of the active region of surfactant protein-A (SP-A), a protein that regulates key innate immune functions in the lung, and perform a drug screen that identifies those most active and stable with similar…